Human olfactory stem cells for injured facial nerve reconstruction in a rat model. (1st February 2016)

• Record Type: Journal Article
• Authors: Batioglu–Karaaltin, Aysegul; Karaaltin, Mehmet Veli; Oztel, Olga Nehir; Ovali, Ercument; Sener, Belit Merve; Adatepe, Turgut; Yigit, Ozgur; Bozkurt, Erol; Baydar, Serap Yesilkir; Bagirova, Melahat; Uzun, Nurten; Allahverdiyev, Adil
• Is Part Of: Head & neck. Volume 38(2016)Supplement 1
• Page Start: E2011
• Page End: E2020
• Publication Date: 2016-02-01
• Subjects: facial nerve -- axonal nerve damage -- olfactory mucosa -- stem cells -- reconstruction; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24371
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: The purpose of this study was to show the efficacy of olfactory stem cells for injured facial nerve reconstruction in a rat model. Methods: Olfactory stem cells were isolated from the olfactory mucosa of human participants. A 2‐mm excision was performed on the right facial nerve of all rats. Reconstruction was performed with a conduit in group 1 ( n = 9); a conduit and phosphate‐buffered saline in group 2 ( n = 9); and a conduit and labeled olfactory stem cell in group 3 ( n = 9). Rats were followed for whisker movements and electroneuronography (ENoG) analyses. Results: The whisker‐movement scores for group 3 were significantly different from other groups ( p < .001). ENoG showed that the amplitude values for group 3 were significantly different from group 1 and group 2 ( p = .030; p < .001). Group 3 showed marked olfactory stem cell under a fluorescence microscope. Conclusion: This study suggests that olfactory stem cells may be used as a potent cellular therapy for accelerating the regeneration of peripheral nerve injuries. © 2016 Wiley Periodicals, Inc. Head Neck 38 : E2011–E2020, 2016