Impact of elective neck dissection on the outcome of oral squamous cell carcinomas arising in the maxillary alveolus and hard palate. (28th November 2015)

• Record Type: Journal Article
• Authors: Givi, Babak; Eskander, Antoine; Awad, Mahmoud I.; Kong, Qin; Montero, Pablo H.; Palmer, Frank L.; Xu, Wei; De Almeida, John R.; Lee, Nancy; O'Sullivan, Brian; Irish, Jonathan C.; Gilbert, Ralph; Ganly, Ian; Patel, Snehal G.; Goldstein, David P.; Morris, Luc G.T.
• Is Part Of: Head & neck. Volume 38(2016)Supplement 1
• Page Start: E1688
• Page End: E1694
• Publication Date: 2015-11-28
• Subjects: squamous cell carcinoma of head and neck -- maxillary neoplasms -- hard palate -- lymphatic metastasis -- neck dissection -- disease free survival -- treatment outcome; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24302
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Whether elective lymph neck dissection (ELND) is associated with improved survival in oral squamous cell carcinomas (SCC) of the maxillary alveolus/hard palate is not known. Methods: One hundred ninety‐nine patients presenting de novo and receiving treatment for clinically node negative SCC of the maxillary alveolus/hard palate at 2 cancer centers between 1985 and 2011 were analyzed. Results: Forty‐two patients (21%) received ELND. Occult nodal metastases were present in 29% of the dissected necks. The ELND group had more T3 to T4 status tumors (62% vs 34%; p < .001) and positive‐margin resections (59% vs 38%; p = .019). Patients undergoing ELND experienced lower rates of neck recurrence (6% vs 21%; p = .031), superior 5‐year recurrence‐free survival (68% vs 45%; p = .026), and overall survival (86% vs 62%; p = .043). ELND was associated with a 2‐fold decrease in risk of recurrence in multivariable analysis. Conclusion: ELND was associated with lower rates of recurrence and improved survival in SCC of the maxillary alveolus/hard palate. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E1688–E1694, 2016