Past and future impact of next‐generation sequencing in head and neck cancer. (20th July 2015)

• Record Type: Journal Article
• Authors: Sethi, Neeraj; MacLennan, Kenneth; Wood, Henry M.; Rabbitts, Pamela
• Other Names: Ha Patrick K. sponsoringEditor.
• Is Part Of: Head & neck. Volume 38(2016)Supplement 1
• Page Start: E2395
• Page End: E2402
• Publication Date: 2015-07-20
• Subjects: next‐generation sequencing -- head and neck cancer -- Sanger sequencing -- human papillomavirus -- genomics; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24085
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Progress in sequencing technology is intrinsically linked to progress in understanding cancer genomics. The purpose of this review was to discuss the development from Sanger sequencing to next‐generation sequencing (NGS) technology. We highlight the technical considerations for understanding reports using NGS. We discuss the findings of studies in head and neck cancer using NGS as well as The Cancer Genome Atlas. Finally we discuss future routes for research utilizing this methodology and the potential impact of this. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E2395–E2402, 2016