Detection of subclinical recurrence or second primary cancer using 18F‐FDG PET/CT in patients treated curatively for head and neck squamous cell carcinoma. (14th July 2015)

• Record Type: Journal Article
• Authors: Kikuchi, Masahiro; Shinohara, Shogo; Hino, Megumu; Itoh, Kyo; Tona, Risa; Kishimoto, Ippei; Harada, Hiroyuki; Fujiwara, Keizo; Suehiro, Atsushi; Naito, Yasushi
• Is Part Of: Head & neck. Volume 38(2016)Supplement 1
• Page Start: E511
• Page End: E518
• Publication Date: 2015-07-14
• Subjects: surveillance -- head and neck cancer -- 18F‐fluorodeoxyglucose positron emission tomography (18F‐FDG PET)/CT -- recurrence -- second primary cancer; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24032
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract : Background: The efficacy of posttreatment surveillance 18 F‐fluorodeoxyglucose positron emission tomography ( 18 F‐FDG PET)/CT was evaluated in patients with head and neck squamous cell carcinoma (HNSCC). Methods: The subjects were 158 patients with HNSCC who underwent PET/CT after definitive treatment. PET/CT detection of subclinical recurrence or a second primary cancer and the effect of timing of PET/CT scans on survival were analyzed. Results: Recurrence or a second primary cancer occurred in 70 patients, and 67% of these cases were detected by PET/CT. Detection rates were 17%, 9%, 5%, and 5% in the first, second, third, and fourth scans at 4, 9, 15, and 21 months, respectively. In multivariate analysis, patients who underwent early first scans had significantly better disease‐specific (hazard ratio [HR] = 0.37; p = .031) and overall (HR = 0.45; p = .040) survival compared with those who underwent late first scans. Conclusion: Earlier detection of subclinical lesions by surveillance PET/CT within 4 months after treatment may improve survival in patients with HNSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E511–E518, 2016