Intestinal type adenocarcinoma of the ethmoid: Outcomes of a treatment regimen based on endoscopic surgery with or without radiotherapy. (4th September 2015)

• Record Type: Journal Article
• Authors: Nicolai, Piero; Schreiber, Alberto; Bolzoni Villaret, Andrea; Lombardi, Davide; Morassi, Laura; Raffetti, Elena; Donato, Francesco; Battaglia, Paolo; Turri–Zanoni, Mario; Bignami, Maurizio; Castelnuovo, Paolo
• Is Part Of: Head & neck. Volume 38(2016)Supplement 1
• Page Start: E996
• Page End: E1003
• Publication Date: 2015-09-04
• Subjects: intestinal‐type adenocarcinoma -- endoscopic surgery -- ethmoid -- sinonasal tumors -- endoscopy; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24144
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: The purpose of this study was to assess survival, prognostic factors, and complications in a cohort of patients with intestinal‐type adenocarcinoma (ITAC) treated with transnasal endoscopic surgery ± radiotherapy (RT). Methods: Patients with ITAC who underwent endoscopic surgery ± RT at 2 tertiary centers were retrospectively reviewed. Overall survival (OS) and event‐free survival were calculated, and statistically significant variables were entered in a multivariate Cox regression model. Complications were also analyzed. Results: One hundred‐sixty‐nine patients were included. Major complications occurred in 9.5% of patients. Adjuvant RT was delivered in 58.6% of patients. Five‐year OS and event‐free survival were 68.9% and 63.6%, respectively. Advanced pT classification, high‐grade, and positive surgical margins were independently predictive of poor survival. Conclusion: Endoscopic surgery ± RT is a valid treatment option in most cases of ITAC. When compared with series based on external surgery, our results support a definitive paradigm shift in the management of ITAC. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E996–E1003, 2016