Neuroendocrine neoplasms of the sinonasal region. (18th July 2015)

• Record Type: Journal Article
• Authors: Bell, Diana; Hanna, Ehab Y.; Weber, Randal S.; DeMonte, Franco; Triantafyllou, Asterios; Lewis, James S.; Cardesa, Antonio; Slootweg, Pieter J.; Stenman, Göran; Gnepp, Douglas R.; Devaney, Kenneth O.; Rodrigo, Juan P.; Rinaldo, Alessandra; Wenig, Bruce M.; Westra, William H.; Bishop, Justin A.; Hellquist, Henrik; Hunt, Jennifer L.; Kusafuka, Kimihide; Perez–Ordoñez, Bayardo; Williams, Michelle D.; Takes, Robert P.; Ferlito, Alfio
• Other Names: Eisele David W. sponsoringEditor.
• Is Part Of: Head & neck. Volume 38(2016)Supplement 1
• Page Start: E2259
• Page End: E2266
• Publication Date: 2015-07-18
• Subjects: neuroendocrine neoplasms -- olfactory neuroblastoma -- sinonasal carcinoma -- immunohistochemistry -- sinonasal undifferentiated carcinoma; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24152
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Neuroendocrine neoplasms of the sinonasal region, which are relatively uncommon but clinically very important, are reviewed here in the light of current knowledge. Using a definition for neuroendocrine based on phenotypic, histologic, immunohistochemical, and electron microscopic features rather than histogenetic criteria, sinonasal neuroendocrine carcinomas are examined with a particular emphasis on the small‐cell and large‐cell subtypes. This is followed by revisiting olfactory neuroblastoma because it is also a tumor that shows a neuroendocrine phenotype. Kadish clinical and Hyams histologic grading systems as prognosticators of olfactory neuroblastoma are also considered in detail. Finally, controversies regarding sinonasal undifferentiated carcinoma as a neuroendocrine tumor are discussed and a possible relationship with high‐grade olfactory neuroblastoma is explored. Genetic events and current management of these tumors are also outlined. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E2259–E2266, 2016