Clinical significance of melanoma‐associated antigen A1–6 expression in sputum of patients with squamous cell carcinoma of the larynx and hypopharynx. (18th July 2015)

• Record Type: Journal Article
• Authors: Lee, Kang Dae; Lee, Hyoung Shin; Kim, Sung Won; Park, Taejung; Hong, Jong Chul; Chang, Hee Kyung; Jung, Sang Bong; Jeon, Chang‐Ho; Park, Jong Wook
• Is Part Of: Head & neck. Volume 38(2016)Supplement 1
• Page Start: E736
• Page End: E740
• Publication Date: 2015-07-18
• Subjects: squamous cell carcinoma -- larynx -- hypopharynx -- head and neck cancer -- melanoma‐associated antigen (MAGE); Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24081
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Several studies have reported the expression of the melanoma‐associated antigen (MAGE) gene in head and neck squamous cell carcinoma (HNSCC). In this study, we evaluated the correlations between MAGE expression in sputum and the clinical features and oncologic outcomes of SCC of the larynx and hypopharynx. Methods: We performed a retrospective review of 119 patients treated for SCC of the larynx and hypopharynx and analysis of their induced sputum by nested reverse transcription‐polymerase chain reaction (RT‐PCR) to detect the MAGE‐A1–6 gene. The associations between MAGE expression and clinical characteristics were analyzed. Results: Expression of MAGE‐A1–6 in sputum was identified in 57 of 119 patients (47.9%), and was independently correlated to double primary cancer ( p = .024; odds ratio [OR] = 4.135). Expression of MAGE‐A1–6 in sputum was correlated to poor survival. Conclusion: Expression of MAGE‐A1–6 in sputum predicts poor oncologic outcome in patients with SCC of the larynx and hypopharynx. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E736–E740, 2016