Risk of second primary malignancy after nasopharyngeal carcinoma in the United States: A population‐based study. (28th August 2015)

• Record Type: Journal Article
• Authors: Chan, Jason Y. K.; Gooi, Zhen; Mydlarz, Wojciech K.; Agrawal, Nishant
• Is Part Of: Head & neck. Volume 38(2016)Supplement 1
• Page Start: E1130
• Page End: E1136
• Publication Date: 2015-08-28
• Subjects: nasopharyngeal carcinoma -- second primary cancer -- survival -- oral cavity cancer -- disease surveillance; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24173
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: The purpose of this study was to evaluate the incidence of second primary malignancies in patients diagnosed with an index nasopharyngeal carcinoma (NPC) in the United States. Methods: The cohort was assembled from the Surveillance, Epidemiology, and End Results (SEER) database with a primary NPC between 1973 and 2005. Results: There was a 47% increased risk of second primary malignancy. The sites with increased risk include the oral cavity and pharynx (standardized incidence ratio [SIR] = 7.11; 95% confidence interval [CI] = 5.21–9.49), esophagus (SIR = 3.50; 95% CI = 1.68–6.44), nose, nasal cavity, and middle ear (SIR = 15.54; 95% CI = 5.70–33.83), and lung and bronchus (SIR = 2.39; 95% CI = 1.91–2.96). Conclusion: Patients with NPC are likely at a significant risk for second primary malignancies, most notably in the oral cavity and pharynx, which is most likely related to genetic susceptibility, increased surveillance, and treatment effects. © 2015 Wiley Periodicals, Inc. Head Neck 38 : E1130–E1136, 2016