Increasing Diagnostic Uncertainties in Children With In Utero HIV Infection. Issue 8 (August 2019)

• Record Type: Journal Article
• Authors: Millar, Jane R.; Mvo, Zodumo; Bengu, Nomonde; Fillis, Rowena; Sprenger, Ken; Matthews, Philippa C.; Archary, Moherndran; Ndung'u, Thumbi; Adland, Emily; Puertas, Maria C.; Martinez-Picado, Javier; Goulder, Philip
• Is Part Of: Pediatric infectious disease journal. Volume 38:Issue 8(2019)
• Publication Date: 2019-08
• Subjects: point-of-care test -- in utero HIV infection -- prevention of mother-to-child transmission; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000002315
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : We present a case of an in utero HIV-infected child, who on day 1 of life had a positive whole blood total nucleic acid test but viral load <20 RNA copies/mL. Dried blood spot total nucleic acid testing was negative on day 1, 10 and at 3 months, while on ART prophylaxis then positive at 5 months after prophylaxis ended. Retrospective peripheral blood mononuclear cells HIV DNA testing from day 1 of life was positive, confirming in utero infection. Abstract : Supplemental Digital Content is available in the text.