Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration. Issue 33 (24th May 2019)

• Record Type: Journal Article
• Authors: Xu, Duo; Wu, Di; Qin, Meng; Nih, Lina R.; Liu, Chaoyong; Cao, Zheng; Ren, Jie; Chen, Xiangjun; He, Zhanlong; Yu, Wenhai; Guan, Jiaoqiong; Duan, Suqin; Liu, Fang; Liu, Xiangsheng; Li, Jesse; Harley, Dushawn; Xu, Bin; Hou, Lihua; Chen, Irvin S. Y.; Wen, Jing; Chen, Wei; Pourtaheri, Sina; Lu, Yunfeng
• Is Part Of: Advanced materials. Volume 31:Issue 33(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-05-24
• Subjects: blood–brain barrier -- central nervous system -- nerve growth factors -- neural regeneration -- spinal cord injury; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201900727
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: The central nervous system (CNS) plays a central role in the control of sensory and motor functions, and the disruption of its barriers can result in severe and debilitating neurological disorders. Neurotrophins are promising therapeutic agents for neural regeneration in the damaged CNS. However, their penetration across the blood–brain barrier remains a formidable challenge, representing a bottleneck for brain and spinal cord therapy. Herein, a nanocapsule‐based delivery system is reported that enables intravenously injected nerve growth factor (NGF) to enter the CNS in healthy mice and nonhuman primates. Under pathological conditions, the delivery of NGF enables neural regeneration, tissue remodeling, and functional recovery in mice with spinal cord injury. This technology can be utilized to deliver other neurotrophins and growth factors to the CNS, opening a new avenue for tissue engineering and the treatment of CNS disorders and neurodegenerative diseases. Abstract : A nanocapsule‐based strategy is developed to efficiently deliver nerve growth factor (NGF) to the central nervous system (CNS) in mice and nonhuman primates. Under pathological conditions, the delivery of NGF enables neural regeneration, tissue remodeling, and functional recovery in mice with spinal cord injury. This work opens new avenues for the treatment of CNS diseases and injuries.