Copper‐Catalyzed Tandem C−H/N−H Activation, Cyclization[4+2] and Dehydration of Arylamides with Formamide: Synthesis of 4(3H)‐Quinazolinones Derivatives. Issue 12 (27th May 2019)

• Record Type: Journal Article
• Authors: Sun, Jian; Wang, Guodong; Hao, Liqiang; Han, Junfen; Li, Hongshuang; Duan, Guiyun; You, Guirong; Li, Furong; Xia, Chengcai
• Is Part Of: ChemCatChem. Volume 11:Issue 12(2019)
• Page Start: 2799
• Page End: 2802
• Publication Date: 2019-05-27
• Subjects: 4(3H)-quinazolinones -- tandem C−H/N−H activation -- 8-aminoquinoline -- formamide -- copper-catalyzed; Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201900445
• Languages: English
• ISSNs: 1867-3880

Abstract

Abstract: A novel route for copper‐catalyzed tandem C−H/N−H activation, cyclization[4+2] and dehydration of arylamides with formamide to synthesize 4(3H)‐quinazolinone derivatives was developed. This approach is assisted by an 8‐aminoquinoline group and the formamide provide the nitrogen and carbon source. This reaction is compatible with various functional groups, and the reaction conditions are mild. In addition, it uses cheaply and commercially available reagents, and provides direct access to 4(3H)‐quinazolinones. Abstract : Copper does the trick : Cheap and commercially available CuCl catalyzes the tandem C−H/N−H activation, [4+2] cyclization and dehydration of arylamides with formamide to synthesize 4(3H)‐quinazolinone derivatives with good functional group compatibility under mild reaction conditions.