A Desulfurative Strategy for the Generation of Alkyl Radicals Enabled by Visible‐Light Photoredox Catalysis. Issue 22 (7th May 2018)

• Record Type: Journal Article
• Authors: Xue, Fei; Wang, Falu; Liu, Jiazhen; Di, Jiamei; Liao, Qi; Lu, Huifang; Zhu, Min; He, Liping; He, Huan; Zhang, Dan; Song, Hao; Liu, Xiao‐Yu; Qin, Yong
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 22(2018)
• Page Start: 6667
• Page End: 6671
• Publication Date: 2018-05-07
• Subjects: alkyl radicals -- conjugate addition -- desulfuration -- photoredox catalysis -- radical reactions; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201802710
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Herein, we present a new desulfurative method for generating primary, secondary, and tertiary alkyl radicals through visible‐light photoredox catalysis. A process that involves the generation of N‐centered radicals from sulfinamide intermediates, followed by subsequent fragmentation, is critical to forming the corresponding alkyl radical species. This strategy has been successfully applied to conjugate addition reactions that features mild reaction conditions, broad substrate scope (>60 examples), and good functional‐group tolerance. Abstract : Easy as 1°2°3° : A new desulfurative method for generating primary, secondary, and tertiary alkyl radicals through visible‐light photoredox catalysis is reported. The key process for forming the alkyl radical species involves the generation of N‐centered radicals from sulfinamide intermediates, followed by fragmentation.