Inhibit, switch, and update: A within-subject fMRI investigation of executive control. (September 2019)

• Record Type: Journal Article
• Authors: Lemire-Rodger, Sabrina; Lam, Jaeger; Viviano, Joseph D.; Stevens, W. Dale; Spreng, R. Nathan; Turner, Gary R.
• Is Part Of: Neuropsychologia. Volume 132(2019)
• Publication Date: 2019-09
• Subjects: Executive function -- Prefrontal cortex -- Cognitive control -- Working memory -- Inhibition -- Task switching -- Networks -- Frontoparietal control; Neuropsychology -- Periodicals; Neurology -- Periodicals; Psychophysiology -- Periodicals; Neuropsychologie -- Périodiques; Neuropsychology; Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.neuropsychologia.2019.107134
• Languages: English
• ISSNs: 0028-3932

Abstract

Abstract: An influential model of executive control suggests that it comprises three dissociable processes: working memory, inhibition, and task switching. Multiple studies have investigated how these processes are individually implemented in the human brain. However, few have directly investigated this question using a common task architecture and a within-subject design. Here, healthy adult humans (N = 22) performed a novel executive control task during fMRI scanning. The paradigm independently manipulated working memory updating, inhibition, and task switching demands, while keeping all other task features constant. Direct contrasts of each executive task with a closely matched control condition revealed a differentiated pattern of recruitment across control tasks: working memory was associated with activity in dorsolateral prefrontal, lateral parietal and insular cortices bilaterally; Inhibition engaged right lateral and superior medial prefrontal cortex, inferior parietal lobules bilaterally, right middle and inferior temporal cortex, and ventral visual processing regions; Task switching was associated with bilateral activity in medial prefrontal cortex, posterior cingulate cortex and precuneus, as well as left inferior parietal lobule, lateral temporal cortex and right thalamus. A conjunction of all executive versus control task activations revealed common areas of activation overlapping regions of canonical frontoparietal control and dorsal attention networks. Further, multivariate analyses suggest that working memory may be a putative common factor supporting executive functioning. Taken together, these results are consistent with a hybrid model of executive control in the human brain. Graphical abstract: Image 1 Highlights: Within-subject fMRI investigation of executive control processes. Novel matched-tasks paradigm with univariate and multivariate analyses. Common executive control network co-occurs with process-specific brain activity. Support for hybrid model of executive control in the human brain. Working memory may be a superordinate feature of executive control.