Neuregulin-1/ErbB network: An emerging modulator of nervous system injury and repair. (September 2019)

• Record Type: Journal Article
• Authors: Kataria, Hardeep; Alizadeh, Arsalan; Karimi-Abdolrezaee, Soheila
• Is Part Of: Progress in neurobiology. Volume 180(2019)
• Publication Date: 2019-09
• Subjects: AChR acetylcholine receptor -- AD Alzheimer's disease -- ADAM a disintegrin and metalloproteinase -- ALS amyotrophic lateral sclerosis -- AMPA α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid -- ARIA acetylcholine receptor inducing activity -- ASD autism spectrum disorder -- BACE β-site of amyloid precursor protein cleaving enzyme -- BBB blood brain barrier -- Breg regulatory B cell -- CCL C-C motif ligand -- CDK cyclin dependent kinase -- CEMIP Cell Migration Inducing Protein -- CHN congenital hypomyelinating neuropathy -- CMT1A Charcot-Marie-Tooth 1A -- CNS central nervous system -- CRD cysteine-rich domain -- CSPGs chondroitin sulfate proteoglycans -- CXCL C-X-C motif ligand -- DA dopamine -- DAT dopamine transporter -- DC dendritic cell -- DFP diisopropylfluorophosphate -- Dlx2 distal-less homeobox 2 -- DRG dorsal root ganglion -- EAAC excitatory amino acid carrier -- EAE experimental autoimmune encephalomyelitis -- ECM extracellular matrix -- ErbB erythroblastic leukemia viral oncogene homolog -- EGF epidermal growth factor -- Egr2 early growth response protein 2 -- ErbB erythroblastic oncogene B -- ERK extracellular signal-regulated kinase -- FAK focal adhesion kinase -- FDA food and drug administration -- GABA γ-aminobutyric acid -- GDNF glial cell line derived neurotrophic factor -- GGF glial growth factor -- HSPGs heparan-sulfate proteoglycans -- I-CLiP intramembrane-cleaving protease -- IL interleukin -- Ig immunoglobulin -- ICD intracellular domain -- IFN-γ interferon gamma -- iNOS inducible nitric oxide synthase -- JNK c-Jun N-terminal kinase -- KA kainic acid -- LPC Lysophosphatidylcholine -- LPS Lipopolysaccharide -- MAPK mitogen activated protein kinase -- MEK MAPK/ERK kinase -- mGluR1 metabotropic glutamate receptor 1 -- Mpz myelin protein zero -- MS multiple sclerosis -- MuSK muscle specific kinase -- NCC neural crest cells -- NF-? ?B nuclear factor kappa-light-chain-enhancer of activated B cells -- NGF nerve growth factor -- NMJ neuromuscular junction -- Nrg-1 neuregulin-1 -- NMDA N-methyl-D-aspartate -- NPC neural precursor cells -- NT-3 neurotrophin-3 -- O2A oligodendrocyte-type-2 astrocyte -- Omg oligodendrocyte myelin glycoprotein -- OPCs oligodendrocyte precursor cells -- P75NTR P75 neurotrophin receptor -- PD Parkinson's disease -- PI3K phosphatidylinositol 3-kinase -- PKC protein kinase C -- PLC phospholipase C -- Pmp2 peripheral myelin protein 2 -- PNS peripheral nervous system -- PPI prepulse inhibition -- PS1 presenilin-1 -- PSD-95 postsynaptic density protein of 95 kDa -- RAF rapidly accelerated fibrosarcoma -- RANTES Regulated on Activation Normal T Expressed and Secreted -- RMS rostral migratory stream -- Shp2 Src homology region 2-containing protein tyrosine phosphatase 2 -- SNP single-nucleotide polymorphism -- SOD1 superoxide dismutase 1 -- TACE Tumor necrosis factor-alpha converting enzyme -- TGF-β transforming growth factor beta -- TLR toll-like receptor -- TM transmembrane domain -- TNF tumor necrosis factor -- Treg regulatory T cell -- tSCs terminal Schwann cells -- YY1 Yin Yang 1; Neuregulin-1 -- ErbB signaling -- CNS injury and repair -- PNS injury -- Myelination and myelin repair -- Neuroinflammation; Neurobiology -- Periodicals; Neurology -- Periodicals; Neurology -- Periodicals; Neurobiologie -- Périodiques; 612.8
• DOI: 10.1016/j.pneurobio.2019.101643
• Languages: English
• ISSNs: 0301-0082

Abstract

Abstract: Neuregulin-1 (Nrg-1) is a member of the Neuregulin family of growth factors with essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg-1 type I-VI) and over 30 isoforms have been discovered; however, their specific roles are not fully determined. Nrg-1 signals through a complex network of protein-tyrosine kinase receptors, ErbB2, ErbB3, ErbB4 and multiple intracellular pathways. Genetic and pharmacological studies of Nrg-1 and ErbB receptors have identified a critical role for Nrg-1/ErbB network in neurodevelopment including neuronal migration, neural differentiation, myelination as well as formation of synapses and neuromuscular junctions. Nrg-1 signaling is best known for its characterized role in development and repair of the peripheral nervous system (PNS) due to its essential role in Schwann cell development, survival and myelination. However, our knowledge of the impact of Nrg-1/ErbB on the central nervous system (CNS) has emerged in recent years. Ongoing efforts have uncovered a multi-faceted role for Nrg-1 in regulating CNS injury and repair processes. In this review, we provide a timely overview of the most recent updates on Nrg-1 signaling and its role in nervous system injury and diseases. We will specifically highlight the emerging role of Nrg-1 in modulating the glial and immune responses and its capacity to foster neuroprotection and remyelination in CNS injury. Nrg-1/ErbB network is a key regulatory pathway in the developing nervous system; therefore, unraveling its role in neuropathology and repair can aid in development of new therapeutic approaches for nervous system injuries and associated disorders.