Reduced semantic control in older adults is linked to intrinsic DMN connectivity. (September 2019)

• Record Type: Journal Article
• Authors: Krieger-Redwood, Katya; Wang, Hao-Ting; Poerio, Giulia; Martinon, Léa M.; Riby, Leigh M.; Smallwood, Jonathan; Jefferies, Elizabeth
• Is Part Of: Neuropsychologia. Volume 132(2019)
• Publication Date: 2019-09
• Subjects: Semantic -- DMN -- Ageing -- Control; Neuropsychology -- Periodicals; Neurology -- Periodicals; Psychophysiology -- Periodicals; Neuropsychologie -- Périodiques; Neuropsychology; Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.neuropsychologia.2019.107133
• Languages: English
• ISSNs: 0028-3932

Abstract

Abstract: Ageing provides an interesting window into semantic cognition: while younger adults generally outperform older adults on many cognitive tasks, knowledge continues to accumulate over the lifespan and consequently, the semantic store (i.e., vocabulary size) remains stable (or even improves) during healthy ageing. Semantic cognition involves the interaction of at least two components – a semantic store and control processes that interact to ensure efficient and context-relevant use of representations. Given older adults perform less well on tasks measuring executive control, their ability to access the semantic store in a goal driven manner may be compromised. Older adults also consistently show reductions in intrinsic brain connectivity, and we examined how these brain changes relate to age-related changes in semantic performance. We found that while older participants outperformed their younger counterparts on tests of vocabulary size (i.e., NART), younger participants were faster and more accurate in tasks requiring semantic control, and these age differences correlated with measures of intrinsic connectivity between the anterior temporal lobe (ATL) and medial prefrontal cortex (mPFC), within the default mode network. Higher intrinsic connectivity from right ATL to mPFC at rest related to better performance on verbal (but not picture) semantic tasks, and older adults showed an exaggerated version of this pattern, suggesting that this within-DMN connectivity may become more important for conceptual access from words as we age. However, this appeared to be at the expense of control over semantic retrieval – there was little relationship between connectivity and performance for strong associations in either group, but older adults with stronger connectivity showed particularly inefficient retrieval of weak associations. Older adults may struggle to harness the default mode network to support demanding patterns of semantic retrieval, resulting in a performance cost. Highlights: Older adults have a greater vocabulary size, but with reduced semantic control. Within DMN connectivity (RATL to mPFC) for access to verbal (not picture) semantics. Increased RATL-mPFC connectivity linked to reduced semantic control in older adults.