Visible Light Activation of Spin‐Silenced Fluorescence. Issue 47 (24th May 2018)

• Record Type: Journal Article
• Authors: Eing, Matthias; Tuten, Bryan T.; Blinco, James P.; Barner‐Kowollik, Christopher
• Is Part Of: Chemistry. Volume 24:Issue 47(2018)
• Page Start: 12246
• Page End: 12249
• Publication Date: 2018-05-24
• Subjects: fluorescence -- nitroxide chemistry -- sensors -- Ugi reactions -- visible light photochemistry; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201800732
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: A self‐reporting, profluorescent, visible light‐induced release system is introduced. Fluorescence activation is enabled by a mild remote trigger signal that can be monitored with the naked‐eye in real time. The light‐responsive spin‐silenced polymer is synthesized via an Ugi post‐polymerization modification incorporating paramagnetic nitroxides and a light cleavable fluorophore moiety. Abstract : Getting turned on by blue light : We pioneer a visible light‐induced self‐reporting release system, where the cleavage of the molecular cargo is induced by light and read out by a strong visible fluorescence switch‐on. The molecular construct exploits a multi‐component reaction to tether a nitroxide spin‐silenced fluorophore to a macromolecular delivery vector. The visible light‐induced molecular release event can be monitored with the naked eye.