Brief Report: Smoking in Systemic Sclerosis: A Longitudinal European Scleroderma Trials and Research Group Study. Issue 11 (24th September 2018)

• Record Type: Journal Article
• Authors: Jaeger, Veronika K.; Valentini, Gabriele; Hachulla, Eric; Cozzi, Franco; Distler, Oliver; Airó, Paolo; Czirják, Laszlo; Allanore, Yannick; Siegert, Elise; Rosato, Edoardo; Matucci‐Cerinic, Marco; Caimmi, Cristian; Henes, Jörg; Carreira, Patricia E.; Smith, Vanessa; del Galdo, Francesco; Denton, Christopher P.; Ullman, Susanne; De Langhe, Ellen; Riccieri, Valeria; Alegre‐Sancho, Juan J.; Rednic, Simona; Müller‐Ladner, Ulf; Walker, Ulrich A.
• Other Names: Ananieva Lidia P. investigator.; Iannone Florenzo investigator.; Distler Jörg H. W. investigator.; Kerzberg Eduardo investigator.; Stamenkovic Bojana investigator.; Da Silva José Antonio Pereira investigator.; Catellví Ivan investigator.; Yavuz Sule investigator.; Solanki Kamal investigator.; Anic Branimir investigator.; Loyo Esthela investigator.; Schmeiser Tim investigator.; Ionescu Ruxandra Maria investigator.; Villiger Peter investigator.; Cantatore Francesco Paolo investigator.; de la Peña Lefebvre Paloma García investigator.; Mihai Carina investigator.; Farge Bancel Dominique investigator.; Farge Bancel Dominique investigator.; Farge Bancel Dominique investigator.; Meroni Pierluigi investigator.; Martin Thierry investigator.; Heitmann Stefan investigator.; Hunzelmann Nicolas investigator.; Oksel Fahrettin investigator.; Bianchi Washington investigator.; Bongiovanni Sara investigator.; Becvar Radim investigator.; Zenone Thierry investigator.; Balbir‐Gurman Alexandra investigator.; Wiland Piotr investigator.; Zebryk Pawel investigator.; Spertini François investigator.; Chung Lori investigator.; Vacca Alessandra investigator.; Chizzolini Carlo investigator.; Selmi Carlo Francesco investigator.; Tanaseanu Cristina‐Mihaela investigator.; Litinsky Ira investigator.; Houssiau Frédéric A. investigator.; Krummel‐Lorenz Brigitte investigator.; Hsu Vivien M. investigator.; Fontes Francisca investigator.; Burlui Alexandra Maria investigator.; Martinovic Duska investigator.; Popa Sergei investigator.; Rosner Itzhak investigator.; Mallia Carmel investigator.; Foti Rosario investigator.; Mouthon Luc investigator.; Aringer Martin investigator.; van Laar Jacob investigator.; Hesselstrand Roger investigator.; Pozzi Maria Rosa investigator.; Riemekasten Gabriela investigator.; Cutolo Maurizio investigator.; Hasler Paul investigator.; Antonio Zea Mendoza investigator.; Sunderkötter Cord investigator.; Ancuta Codrina investigator.; Sibilia Jean investigator.; Caporali Roberto investigator.; Gabrielli Armando investigator.; Pellerito Raffaele investigator.; Herrick Ariane investigator.; Midtvedt Øyvind investigator.; Eyerich Kilian investigator.; Granel Brigitte investigator.; Saketkoo Lesley Ann investigator.; Couto Maura investigator.; Eizikovits Yael investigator.; Abignano Giuseppina investigator.;
• Is Part Of: Arthritis & rheumatology. Volume 70:Issue 11(2018)
• Page Start: 1829
• Page End: 1834
• Publication Date: 2018-09-24
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/art.40557
• Languages: English
• ISSNs: 2326-5191

Abstract

Abstract : Objective: Data on the role of tobacco exposure in systemic sclerosis (SSc; scleroderma) severity and progression are scarce. We aimed to assess the effects of smoking on the evolution of pulmonary and skin manifestations, based on the European Scleroderma Trials and Research group database. Methods: Adult SSc patients with data on smoking history and a 12–24‐month follow‐up visit were included. Associations of severity and progression of organ involvement with smoking history and the Comprehensive Smoking Index were assessed using multivariable regression analyses. Results: A total of 3, 319 patients were included (mean age 57 years, 85% female); 66% were never smokers, 23% were ex‐smokers, and 11% were current smokers. Current smokers had a lower percentage of antitopoisomerase autoantibodies than previous or never smokers (31% versus 40% and 45%, respectively). Never smokers had a higher baseline forced expiratory volume in 1 second/forced vital capacity (FEV1 /FVC) ratio than previous and current smokers ( P < 0.001). The FEV1 /FVC ratio declined faster in current smokers than in never smokers ( P = 0.05) or ex‐smokers ( P = 0.01). The baseline modified Rodnan skin thickness score (MRSS) and the MRSS decline were comparable across smoking groups. Although heavy smoking (>25 pack‐years) increased the odds of digital ulcers by almost 50%, there was no robust adverse association of smoking with digital ulcer development. Conclusion: The known adverse effect of smoking on bronchial airways and alveoli is also observed in SSc patients; however, robust adverse effects of smoking on the progression of SSc‐specific pulmonary or cutaneous manifestations were not observed.