The updated grading system of prostate carcinoma: an inter‐observer agreement study among general pathologists in an academic practice. Issue 11 (15th September 2017)

• Record Type: Journal Article
• Authors: Al Nemer, Areej M.; Elsharkawy, Tarek; Elshawarby, Mohamed; Al‐Tamimi, Dalal; Kussaibi, Haitham; Ahmed, Ayesha
• Is Part Of: Apmis. Volume 125:Issue 11(2017:Nov.)
• Page Start: 957
• Page End: 961
• Publication Date: 2017-09-15
• Subjects: Prostate cancer -- Gleason -- grading -- grade groups -- reproducibility; Pathology -- Periodicals; Microbiology -- Periodicals; Immunology -- Periodicals; 572
• DOI: 10.1111/apm.12741
• Languages: English
• ISSNs: 0903-4641

Abstract

Abstract : In 2016, the grading criteria for Gleason scoring (GS) have been updated in the WHO classification of tumors of the prostate, and a new set of grade groups (GG) was introduced. As the inter‐observer discordance is a well‐known concern in Gleason grading before the update and no reproducibility study testing the grade groups exists, we planned to evaluate the inter‐observer agreement of the most updated grading system. Four pathologists assessed 126 cores of prostatic carcinoma, and Kappa (k) test was calculated. The agreements for both GS and GG were substantial (k = 0.753 and 0.752; respectively). Discerning GG 2 from 3 also attained reasonable outcome (k = 0.675). Based on our results, the updated grading system seems to be reproducible, with satisfactory inter‐observer concordance rate.