Relationship between resolution of non‐alcoholic steatohepatitis and changes in lipoprotein sub‐fractions: a post‐hoc analysis of the PIVENS trial. Issue 9 (10th March 2019)

• Record Type: Journal Article
• Authors: Corey, Kathleen E.; Wilson, Laura A.; Altinbas, Akif; Yates, Katherine P.; Kleiner, David E.; Chung, Raymond T.; Krauss, Ronald M.; Chalasani, Naga
• Other Names: Bringman Diane investigator.; Dasarathy Srinivasan investigator.; Feldstein Ariel investigator.; Hawkins Carol investigator.; Liu Yao‐Chang investigator.; McCullough Arthur investigator.; Sargent Ruth investigator.; Stager Margaret investigator.; Abdelmalek Manal investigator.; Diehl Anna Mae investigator.; Gottfried Marcia investigator.; Guy Cynthia investigator.; Killenberg Paul investigator.; Kwan Samantha investigator.; Pan Yi‐Ping investigator.; Piercy Dawn investigator.; Smith Melissa investigator.; Pfeifer Kimberly investigator.; Scheimann Ann O. investigator.; Torbenson Michael investigator.; Bhimalli Prajakta investigator.; Byam Elizabeth investigator.; Cummings Oscar W. investigator.; Klipsch Ann investigator.; Lee Lydia investigator.; Molleston Jean P. investigator.; Ragozzino Linda investigator.; Subbarao Girish investigator.; Vuppalanchi Raj investigator.; Barlow Sarah investigator.; Brunt Elizabeth M. investigator.; Derdoy Jose investigator.; Hoffmann Joyce investigator.; King Debra investigator.; Siegner Joan investigator.; Stewart Susan investigator.; Neuschwander‐Tetri Brent A. investigator.; Thompson Judy investigator.; Abrams Stephanie H. investigator.; Arceo Diana investigator.; Espinosa Denise investigator.; Fairly Leanel Angeli investigator.; Behling Cynthia investigator.; Clark Lisa investigator.; Durelle Janis investigator.; Lavine Joel E. investigator.; Mendoza Susana investigator.; Parman Zana investigator.; Patton Heather investigator.; Schwimmer Jeffrey B. investigator.; Sirlin Claude investigator.; Stein Tanya investigator.; Bambha Kiran investigator.; Bass Nathan M. investigator.; Ferrell Linda D. investigator.; Filipowski Danuta investigator.; Merriman Raphael investigator.; Pabst Mark investigator.; Rosenthal Monique investigator.; Rosenthal Philip investigator.; Steel Tessa investigator.; Coffey Melissa investigator.; Kowdley Kris V. investigator.; Mooney Jody investigator.; Murray Karen F. investigator.; Nelson James investigator.; Saunders Cheryl investigator.; Yeh Matthew investigator.; Young Melissa investigator.; Boyett Sherry investigator.; Bryan Daphne investigator.; Contos Melissa J. investigator.; Fuchs Michael investigator.; Jones Amy investigator.; Luketic Velimir A. C. investigator.; Sandhu Bimalijit investigator.; Sanyal Arun J. investigator.; Sargeant Carol investigator.; White Melanie investigator.; Mohan Parvathi investigator.; Nair Kavita investigator.; Doo Edward investigator.; Hoofnagle Jay investigator.; Robuck Patricia R. investigator.; Huang Terry T.‐K. investigator.; Belt Pat investigator.; Brancati Fred investigator.; Clark Jeanne investigator.; Colvin Ryan investigator.; Donithan Michele investigator.; Green Mika investigator.; Hollick Rosemary investigator.; Isaacson Milana investigator.; Kim Wana investigator.; Lydecker Alison investigator.; Mann Pamela investigator.; Miriel Laura investigator.; Sternberg Alice investigator.; Tonascia James investigator.; Ünalp‐Arida Aynur investigator.; Natta Mark Van investigator.; Wilson Laura investigator.; Yates Kathie investigator.;
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 49:Issue 9(2019)
• Page Start: 1205
• Page End: 1213
• Publication Date: 2019-03-10
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.15216
• Languages: English
• ISSNs: 0269-2813

Abstract

Summary: Background: Dyslipidaemia is frequent in non‐alcoholic steatohepatitis (NASH); however, it is unclear if improvement in liver histology is associated with favourable changes in cardiovascular disease (CVD) risk. Aims: To evaluate the relationship of NASH resolution and lipoprotein subfraction levels, markers of endothelial dysfunction, and macrophage activation. Methods: One hundred and seventeen individuals with NASH who participated in the Pioglitazone vs Vitamin E vs Placebo for the Treatment of Nondiabetic Patients with NASH (PIVENS) trial with paired liver biopsies and serum samples available at baseline and after 96 weeks of treatment were included. Participants in the PIVENS trials received vitamin E, pioglitazone, or placebo for 96 weeks. Lipoprotein subfraction levels, intracellular adhesion molecule 1 (ICAM‐1), vascular cellular adhesion molecule 1 (VCAM‐1), E‐selectin, and sCD163 levels were assessed at baseline and week 96 and their relationship with NASH resolution was examined. Results: Fifty‐seven individuals had NASH resolution and 60 individuals did not have resolution of NASH. NASH resolution was associated with favourable changes in lipoprotein subfraction levels compared to those without NASH resolution. Individuals with resolution of NASH had a significantly increased mean peak LDL diameter (ratio of geometric means [96 weeks vs baseline] 1.007 vs 0.996, P = 0.004), and higher frequency of LDL phenotype A (58% vs 33%, P = 0.003) at week 96, after adjustment for relevant co‐variates including treatment group. No differences in VCAM, ICAM, E‐selectin, or sCD163 levels by NASH resolution were found. Conclusions: NASH resolution is associated with favourable changes in a subset of serum lipoprotein levels. More studies are warranted to understand if these favourable changes are associated with decreased risk of CVD.