Warfarin-induced toxic epidermal necrolysis after mitral valve replacement. (November 2020)

• Record Type: Journal Article
• Authors: Kuroda, Taiyo; Yokoyama, Yukifusa; Yamada, Masao; Yuhara, Satoshi; Hasegawa, Hiroki; Yokote, Jun
• Is Part Of: Asian cardiovascular & thoracic annals. Volume 28:Number 9(2020)
• Page Start: 601
• Page End: 603
• Publication Date: 2020-11
• Subjects: Drug hypersensitivity -- eosinophilia -- heart valve prosthesis implantation -- necrosis -- stevens-johnson syndrome -- warfarin; Heart -- Diseases -- Asia -- Periodicals; Heart -- Diseases -- Pacific Area -- Periodicals; Heart -- Diseases -- Periodicals; Heart -- Surgery -- Asia -- Periodicals; Heart -- Surgery -- Pacific Area -- Periodicals; Heart -- Surgery -- Periodicals; Chest -- Surgery -- Asia -- Periodicals; Chest -- Surgery -- Pacific Area -- Periodicals; Chest -- Surgery -- Periodicals; 617.412
• DOI: 10.1177/0218492320951024
• Languages: English
• ISSNs: 0218-4923

Abstract

Stevens-Johnson syndrome and toxic epidermal necrolysis are rare diseases that cause acute destruction of the epithelium of the skin and mucous membranes, almost always attributable to drugs. However, warfarin-induced Stevens-Johnson syndrome and toxic epidermal necrolysis is extremely rare. We report the case of 71-year-old woman who died due to destructive erosion all over her skin and mucous membranes. She had received a mitral valve prosthesis, and warfarin was prescribed for antithrombotic therapy. A lymphocyte transformation test for drug hypersensitivity and the clinical history confirmed this phenomenon as warfarin-induced toxic epidermal necrolysis.