Clinical potentials of human pluripotent stem cells in lung diseases. Issue 1 (17th June 2014)

• Record Type: Journal Article
• Authors: Quan, Yuan; Wang, Dachun
• Is Part Of: Clinical and translational medicine. Volume 3:Issue 1(2014)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2014-06-17
• Subjects: Induced pluripotent stem cells -- Embryonic stem cells -- Differentiation and characterization -- Lung stem/progenitor cells -- and Lung tissue engineering; Clinical medicine -- Periodicals; Medicine, Experimental -- Periodicals; Medical innovations -- Periodicals; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; 616.027
• DOI: 10.1186/2001-1326-3-15
• Languages: English
• ISSNs: 2001-1326

Abstract

Abstract: Lung possesses very limited regenerative capacity. Failure to maintain homeostasis of lung epithelial cell populations has been implicated in the development of many life‐threatening pulmonary diseases leading to substantial morbidity and mortality worldwide, and currently there is no known cure for these end‐stage pulmonary diseases. Embryonic stem cells (ESCs) and somatic cell‐derived induced pluripotent stem cells (iPSCs) possess unlimited self‐renewal capacity and great potential to differentiate to various cell types of three embryonic germ layers (ectodermal, mesodermal, and endodermal). Therapeutic use of human ESC/iPSC‐derived lung progenitor cells for regeneration of injured or diseased lungs will have an enormous clinical impact. This article provides an overview of recent advances in research on pluripotent stem cells in lung tissue regeneration and discusses technical challenges that must be overcome for their clinical applications in the future.