Ferrimagnetic Nanochains‐Based Mesenchymal Stem Cell Engineering for Highly Efficient Post‐Stroke Recovery. (15th April 2019)

• Record Type: Journal Article
• Authors: Zhang, Tianyuan; Li, Fangyuan; Xu, Qianhao; Wang, Qiyue; Jiang, Xinchi; Liang, Zeyu; Liao, Hongwei; Kong, Xianglei; Liu, Jianan; Wu, Honghui; Zhang, Danping; An, Changhua; Dong, Liang; Lu, Yang; Cao, Hongcui; Kim, Dokyoon; Sun, Jihong; Hyeon, Taeghwan; Gao, Jianqing; Ling, Daishun
• Is Part Of: Advanced functional materials. Volume 29:Number 24(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-04-15
• Subjects: ferrimagnetic iron oxide nanochains -- genetic engineering -- ischemic cerebrum homing -- mesenchymal stem cells -- post‐stroke recovery; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201900603
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Unsatisfactory post‐stroke recovery has long been a negative factor in the prognosis of ischemic stroke due to the lack of pharmacological treatments. Mesenchymal stem cells (MSCs)‐based therapy has recently emerged as a promising strategy redefining stroke treatment; however, its effectiveness has been largely restricted by insufficient therapeutic gene expression and inadequate cell numbers in the ischemic cerebrum. Herein, a non‐viral and magnetic field‐independent gene transfection approach is reported, using magnetosome‐like ferrimagnetic iron oxide nanochains (MFIONs), to genetically engineer MSCs for highly efficient post‐stroke recovery. The 1D MFIONs show efficient cellular uptake by MSCs, which results in highly efficient genetic engineering of MSCs to overexpress brain‐derived neurotrophic factor for treating ischemic cerebrum. Moreover, the internalized MFIONs promote the homing of MSCs to the ischemic cerebrum by upregulating CXCR4. Consequently, a pronounced recovery from ischemic stroke is achieved using MFION‐engineered MSCs in a mouse model. Abstract : One‐dimensional ferrimagnetic iron oxide nanochains are developed as robust non‐viral gene vehicles, which not only significantly enhance therapeutic gene expression but also augment the ischemic cerebrum homing effect of mesenchymal stem cells. Consequently, the engineered stem cells are highly efficient for the treatment of post‐ischemic stroke.