2‐Amino‐5‐arylazothiazole‐Based Derivatives: In Vitro Cytotoxicity, Antioxidant Properties, and Bleomycin‐Dependent DNA Damage. Issue 19 (20th May 2019) - Al‐Anazi, Khalid M.
Abstract: Efficient and inexpensive synthesis of 2‐amino‐5‐arylazothiazoles derivatives was made in simple steps and in good yields. Spectral and physical analyses techniques were applied to prove the structures of all synthesized analogues. It was obvious that the synthesized derivatives exhibited efficient biological activities as antibacterial, antioxidant, and anticancer. The antioxidant activity of the synthesized analogues was explored. In addition, the synthesized 2‐amino‐5‐arylazothiazoles were screened as cytotoxic agents against four well‐known cell lines and the results revealed potent activity of the compounds relative to the results of an antibiotic standard. Abstract : A new approach for synthesis of 2‐amino‐5‐arylazothiazoles derivatives was achieved in simple steps. All synthesized derivatives exhibited efficient anticancer against four well‐known cell lines and the results revealed potent activity of the compounds.