Copper‐Catalyzed Oxidative Alkylation of Vinylic Cβ‐H of Enamides with Cyclic Ethers. Issue 23 (18th June 2019)

• Record Type: Journal Article
• Authors: Ding, Ran; Lu, Wang‐Gang; Ci, Hao; Mao, Yue‐Yuan; Liu, Lei
• Is Part Of: ChemistrySelect. Volume 4:Issue 23(2019)
• Page Start: 6954
• Page End: 6957
• Publication Date: 2019-06-18
• Subjects: alkylation -- cyclic ethers -- enamides -- multi-substituted alkene -- vinylic; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201901837
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A general strategy for the oxidative alkylation of vinylic C β ‐H bond of enamides catalyzed by copper to prepare structurally diverse ethers was developed. Under standard reaction conditions, various cyclic and acyclic enamides reacted well with cyclic ethers to afford the corresponding multi‐substituted alkene products in good yields. In addition, the coupling products could be converted into useful amino alcohol derivatives. The coupling reaction was considered to follow a mechanism based on radical pathway. Abstract : A general strategy for the oxidative alkylation of vinylic C β ‐H of bond of enamides using ethers catalyzed by copper to prepare structurally diverse ethers was developed. Under standard reaction conditions, various cyclic and acyclic enamides reacted well with cyclic ethers to afford the corresponding multi‐substituted alkene products in good yields. In addition, The coupling products could be converted into very useful amino alcohol derivatives.