Ceric Ammonium Nitrate (CAN): An Efficient and Eco‐Friendly Catalyst for One‐Pot Synthesis of Diversely Functionalized Biscoumarins in Aqueous Medium under Ambient Conditions. Issue 19 (16th May 2019)

• Record Type: Journal Article
• Authors: Brahmachari, Goutam; Begam, Sanchari
• Is Part Of: ChemistrySelect. Volume 4:Issue 19(2019)
• Page Start: 5415
• Page End: 5420
• Publication Date: 2019-05-16
• Subjects: Biscoumarins -- Ceric Ammonium Nitrate (CAN) -- Sustainable Chemistry -- Water; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201900961
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: An alternative green protocol for the synthesis of a series of biologically relevant biscoumarin derivatives, 3, 3′‐(arylmethylene)bis(4‐hydroxy‐2 H ‐chromen‐2‐one) (3 ), has been developed from a one‐pot pseudo‐three component reaction between 4‐hydroxycoumarin (1 ) and diverse aromatic aldehydes (2 ) using ceric ammonium nitrate (CAN) as a cheap, eco‐friendly and reusable catalyst in aqueous medium under ambient conditions. The salient features of this protocol are the use of readily available low‐cost and environmentally benign catalyst, use of water as green reaction media, clean reaction profile, high atom‐economy, column‐free purification avoiding the use of toxic organic solvents, large‐scale synthetic applicability, and good to excellent yields. Abstract : Old is Gold: Ceric ammonium nitrate (CAN), a cheap and eco‐friendly substance, has been explored to serve as an efficient and reusable catalyst in designing a green protocol for accessing diverse biscoumarins in water under ambient conditions. The key advances of this protocol are the use of water as reaction media, mild reaction conditions, scaled‐up synthesis, reusability of reaction media, and avoidance of column chromatographic purification.