Genome‐wide meta‐analysis identifies 3 novel loci associated with stroke. Issue 6 (30th November 2018)

• Record Type: Journal Article
• Authors: Malik, Rainer; Rannikmäe, Kristiina; Traylor, Matthew; Georgakis, Marios K.; Sargurupremraj, Muralidharan; Markus, Hugh S.; Hopewell, Jemma C.; Debette, Stephanie; Sudlow, Cathie L. M.; Dichgans, Martin
• Is Part Of: Annals of neurology. Volume 84:Issue 6(2018)
• Page Start: 934
• Page End: 939
• Publication Date: 2018-11-30
• Subjects: Neurology -- Periodicals; Pediatric neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; 616.8
• DOI: 10.1002/ana.25369
• Languages: English
• ISSNs: 0364-5134

Abstract

Abstract : We conducted a European‐only and transancestral genome‐wide association meta‐analysis in 72, 147 stroke patients and 823, 869 controls using data from UK Biobank (UKB) and the MEGASTROKE consortium. We identified an exonic polymorphism in NOS3 (rs1799983, p.Glu298Asp; p = 2.2E‐8, odds ratio [OR] = 1.05, 95% confidence interval [CI] = 1.04–1.07) and variants in an intron of COL4A1 (rs9521634; p = 3.8E‐8, OR = 1.04, 95% CI = 1.03–1.06) and near DYRK1A (rs720470; p = 6.1E‐9, OR = 1.05, 95% CI = 1.03–1.07) at genome‐wide significance for stroke. Effect sizes of known stroke loci were highly correlated between UKB and MEGASTROKE. Using Mendelian randomization, we further show that genetic variation in the nitric oxide synthase–nitric oxide pathway in part affects stroke risk via variation in blood pressure. Ann Neurol 2018;84:934–939