Decreased neonatal hepatitis B virus (HBV) viremia by maternal tenofovir treatment predicts reduced chronic HBV infection in children born to highly viremic mothers. Issue 3 (4th July 2019)

• Record Type: Journal Article
• Authors: Chang, Kai‐Chi; Chang, Mei‐Hwei; Lee, Chien‐Nan; Chang, Chin‐Hao; Wu, Jia‐Feng; Ni, Yen‐Hsuan; Wen, Wan‐Hsin; Shyu, Ming‐Kwang; Lai, Ming‐Wei; Chen, Shih‐Ming; Hu, Jen‐Jan; Lin, Hans Hsienhong; Hsu, Jenn‐Jeih; Mu, Shu‐Chi; Lin, Yu‐Cheng; Liu, Chun‐Jen; Chen, Ding‐Shinn; Lin, Lung‐Huang; Chen, Huey‐Ling
• Other Names: Hwa Hsiao‐Lin investigator.; Su Yi‐Ning investigator.; Shih Jin‐Chung investigator.; Chao Kuang‐Han investigator.; Hsu Hong‐Yuan investigator.; Chiu Yu‐Chun investigator.; Su Tung‐Hung investigator.; Lin Chin‐Chuan investigator.; Lin Pei‐Ying investigator.; Yang Wen‐Rong investigator.; Zhao Lu‐Lu investigator.; Yang Chun‐Kuang investigator.; Chang Yin‐Kuang investigator.; Chen Kuo‐Hu investigator.; Lin Yu‐Hung investigator.; Chen Heng‐Ju investigator.; Pan Hun‐Shan investigator.; Lau Beng‐Huat investigator.; Lee Chyi‐Long investigator.; Cheng Po‐Jen investigator.; Chang Yao‐Lung investigator.; Chiueh Ho‐Yen investigator.; Wang Tzu‐Hao investigator.; Lo Liang‐Ming investigator.; Hsieh Chia‐Lin investigator.; Cheng Shao‐Wen investigator.; Tsai Ming‐Song investigator.; She Bo‐Qing investigator.; Koh King‐Jun investigator.; Hung Yi‐Li investigator.; Lin Hsien‐Ming investigator.; Peng Fu‐Shiang investigator.; Wu Tzee‐Chung investigator.; Chen Chih‐Yao investigator.; Chen Chie‐Pein investigator.; Huang Jian‐Pei investigator.; Yeung Chun‐Yan investigator.; Lin Chen‐Ju investigator.; Chiu Wei‐Tsung investigator.; Wang Duo‐Sheng investigator.; Lin Wen‐Terng investigator.; Hwang Kwei‐Shuai investigator.; Huang Ching‐Feng investigator.;
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 50:Issue 3(2019)
• Page Start: 306
• Page End: 316
• Publication Date: 2019-07-04
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.15321
• Languages: English
• ISSNs: 0269-2813

Abstract

Summary: Background: Maternal anti‐viral treatment prevents mother‐to‐infant transmission of hepatitis B virus (HBV), but the role of neonatal viremia on subsequent HBV infection is not clear. Aims: To investigate the effect of maternal anti‐viral treatment on neonatal serum HBV DNA and hepatitis B surface antigen (HBsAg) in infants born to highly viremic mothers and the roles of neonatal markers in predicting chronic HBV infection in children. Methods: Serum HBV DNA and HBsAg were tested in children. Of the 201 pregnant mothers, 110 received tenofovir during the third trimester. Chronic infection in children was defined by HBsAg seropositivity at 6 or 12 months lasting more than 6 months. Results: The maternal HBV viral loads from baseline to delivery were 8.25 ± 0.48 to 4.29 ± 0.98 log10 IU/mL; and 8.29 ± 0.49 to 8.12 ± 0.68 log10 IU/mL in the tenofovir and control group respectively. Of the 208 children, those in the tenofovir group had a lower rate of neonatal HBV DNA seropositivity at birth (5.22% vs 30.11%, P < 0.0001) and HBsAg seropositivity at 6 months (1.74% vs 11.83%, P = 0.003) and 12 months (1.74% vs 10.75%, P = 0.007). In a first multivariate analysis, maternal HBV DNA level at delivery (odds ratio = 1.70, P = 0.0172) and neonatal HBsAg positivity (odds ratio = 19.37, P < 0.0001) were significantly associated with children's chronic HBV infection. In a second model, neonatal HBV DNA positivity was a strong independent influence variable (odds ratio = 61.89, P = 0.0002). Conclusions: Maternal tenofovir therapy decreased maternal viral load and neonatal viremia. Positive neonatal HBV DNA was highly correlated with chronic HBV infection in children. Clinical Trial Identifier: NCT01312012.