Synthesis and Antimicrobial Activity of Novel Thiazoles with Reactive Functional Groups. Issue 23 (19th June 2019)

• Record Type: Journal Article
• Authors: Grybaitė, Birutė; Vaickelionienė, Rita; Stasevych, Maryna; Komarovska‐Porokhnyavets, Olena; Kantminienė, Kristina; Novikov, Volodymyr; Mickevičius, Vytautas
• Is Part Of: ChemistrySelect. Volume 4:Issue 23(2019)
• Page Start: 6965
• Page End: 6970
• Publication Date: 2019-06-19
• Subjects: amino acids -- cyclization -- naphthalen-1-yl -- reactive intermediates -- p-tolyl; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.201900679
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A series of substituted thiazoles bearing different functional groups, such as carboxyethylamino, carboxyl, chloromethyl, (phenylamino)methyl, ethoxyoxoethyl, methoxyoxoethylidene, ethoxycarbonyl, (methoxy or hydrazinyl)oxopropyl, carbohydrazinyl, formyl, and ((phenyl, carbamothioyl or isonicotinoyl)hydrazono)methyl, incorporated into their structure were synthesized. The synthesized compounds were tested for their antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Mycobacterium luteum bacteria strains, and Candida tenuis and Aspergillus niger fungi. Compounds exhibiting exclusive antifungal activity against Aspergillus niger (MIC 0.9, 1.9 μ g/mL) and Candida tenuis (MIC 7.8 μ g/mL) have been identified among the novel thiazole derivatives. Abstract : This study presents the development and biological evaluation of new thiazoles with reactive functional groups, which can participate in further chemical transformations to form variously substituted thiazole derivatives potentially possessing antimicrobial activity.