Vastus lateralis myocutaneous flap for ischial skin wound following the treatment of epithelioid sarcoma using pazopanib. (2nd June 2020)

• Record Type: Journal Article
• Authors: Tsujii, Masaya; Matsumine, Akihiko; Nakamura, Tomoki; Satonaka, Haruhiko; Sudo, Akihiro
• Is Part Of: Journal of wound care. Volume 29:Number 6(2020)
• Page Start: 335
• Page End: 339
• Publication Date: 2020-06-02
• Subjects: ischial skin ulcer -- pazopanib -- reconstructive surgery -- sarcoma -- vastus lateralis myocutaneous flap; Wounds and injuries -- Treatment -- Periodicals; Wound healing -- Periodicals; 617.1
• DOI: 10.12968/jowc.2020.29.6.335
• Languages: English
• ISSNs: 0969-0700

Abstract

Abstract : Pazopanib, a targeted molecular drug, has been proposed as an effective treatment for soft tissue tumour and as a novel adjuvant therapy. There has been a paradoxical concern that wound healing could be inhibited by its anti-angiogenic properties, especially in reconstructive surgery. This paper reports on a 28-year-old woman who underwent flap surgery due to a skin and soft tissue injury after an effective treatment with pazopanib for refractory epithelioid sarcoma. The flap survived without any complication in off-periods of pazopanib for four weeks before and after the surgery, although it is only recommended that the washout periods of pazopanib commence at least seven days before scheduled surgery.