Genetic Correlates of Fatigue in Individuals with End Stage Renal Disease. (December 2020)

• Record Type: Journal Article
• Authors: Davey, Christine Horvat; Webel, Allison R.; Sehgal, Ashwini R.; Voss, Joachim G.; Hsiao, Chao-Pin; Darrah, Rebecca; Litman, Paul; Perez, Federico; Desai, Niraj B.
• Is Part Of: Western journal of nursing research. Volume 42:Number 12(2020)
• Page Start: 1042
• Page End: 1049
• Publication Date: 2020-12
• Subjects: depression -- end stage renal disease -- fatigue -- gene expression -- hemodialysis; Nursing -- Research -- Periodicals; Nursing -- Periodicals; Nursing -- Research -- West (U.S.) -- Periodicals; Nursing -- West (U.S.) -- Periodicals; Nursing -- Periodicals; Nursing Research -- Periodicals; Soins infirmiers -- Recherche -- Périodiques; Soins infirmiers -- Périodiques; Soins infirmiers -- Recherche -- États-Unis (Ouest) -- Périodiques; Soins infirmiers -- États-Unis (Ouest) -- Périodiques; Soins infirmiers; Recherche; États-Unis (Ouest); Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 610.730702
• DOI: 10.1177/0193945920919911
• Languages: English
• ISSNs: 0193-9459

Abstract

Fatigue is a prevalent symptom associated with decreased quality of life and increased mortality in individuals with end stage renal disease (ESRD), yet causes of fatigue in individuals with ESRD remain poorly understood. We examined gene expression of Neuronal PAS Domain Protein 2 (NPAS2) in relation to patient-reported fatigue in 122 individuals with ESRD. Independent samples t-tests were used to examine NPAS2 gene expression profiles of: non-fatigue versus fatigue. Multivariable regression analyses were used to examine the relationship between fatigue and numerous variables including depression. Participants were approximately 58 years old (+/- 13.2 years), 78% African American ( n = 95), and 72% male ( n = 88). The phenotype of fatigue was not significantly associated with gene expression of NPAS2 but was significantly associated with depression ( p < .001). This study suggests that further research should examine the causal mechanism between depression and fatigue in order to identify genetic factors that could explain the high comorbidity of depression and fatigue.