In the eye of the storm: the right ventricle in COVID-19. (July 2020)

• Record Type: Journal Article
• Authors: Park, John F.; Banerjee, Somanshu; Umar, Soban
• Is Part Of: Pulmonary circulation. Volume 10:Number 3(2020)
• Publication Date: 2020-07
• Subjects: acute respiratory distress syndromes (ARDSs) and acute lung injury -- COVID-19 -- pulmonary embolism -- pulmonary hypertension -- right ventricle function and dysfunction; Pulmonary circulation -- Periodicals; Pulmonary circulation; Electronic journals -- Sciences; Periodicals; 616.24005
• DOI: 10.1177/2045894020936660
• Languages: English
• ISSNs: 2045-8932

Abstract

The corona virus disease of 2019 pandemic caused by the SARS-CoV-2 virus continues to inflict significant morbidity and mortality around the globe. A variety of cardiovascular presentations of SARS-CoV-2 infection have been described so far. However, the impact of SARS-CoV-2 on the right ventricle is largely unknown. Due to its pathophysiologic relevance, the right ventricle finds itself in the eye of the storm of corona virus disease of 2019, placing it at higher risk of failure. Increased afterload from acute respiratory distress syndrome and pulmonary embolism, negative inotropic effects of cytokines, and direct angiotensin converting enzyme 2-mediated cardiac injury from SARS-CoV-2 are potential mechanisms of right ventricle dysfunction in corona virus disease of 2019. Early detection and treatment of right ventricle dysfunction may lead to decreased mortality and improved patient outcomes in corona virus disease of 2019.