Modeling tissue-selective cavitation damage. (15th November 2019)
- Record Type:
- Journal Article
- Title:
- Modeling tissue-selective cavitation damage. (15th November 2019)
- Main Title:
- Modeling tissue-selective cavitation damage
- Authors:
- Mancia, Lauren
Vlaisavljevich, Eli
Yousefi, Nyousha
Rodriguez, Mauro
Ziemlewicz, Timothy J
Lee, Fred T
Henann, David
Franck, Christian
Xu, Zhen
Johnsen, Eric - Abstract:
- Abstract: The destructive growth and collapse of cavitation bubbles are used for therapeutic purposes in focused ultrasound procedures and can contribute to tissue damage in traumatic injuries. Histotripsy is a focused ultrasound procedure that relies on controlled cavitation to homogenize soft tissue. Experimental studies of histotripsy cavitation have shown that the extent of ablation in different tissues depends on tissue mechanical properties and waveform parameters. Variable tissue susceptibility to the large stresses, strains, and strain rates developed by cavitation bubbles has been suggested as a basis for localized liver tumor treatments that spare large vessels and bile ducts. However, field quantities developed within microns of cavitation bubbles are too localized and transient to measure in experiments. Previous numerical studies have attempted to circumvent this challenge but made limited use of realistic tissue property data. In this study, numerical simulations are used to calculate stress, strain, and strain rate fields produced by bubble oscillation under histotripsy forcing in a variety of tissues with literature-sourced viscoelastic and acoustic properties. Strain field calculations are then used to predict a theoretical damage radius using tissue ultimate strain data. Simulation results support the hypothesis that differential tissue responses could be used to design tissue-selective treatments. Results agree with studies correlating tissue ultimateAbstract: The destructive growth and collapse of cavitation bubbles are used for therapeutic purposes in focused ultrasound procedures and can contribute to tissue damage in traumatic injuries. Histotripsy is a focused ultrasound procedure that relies on controlled cavitation to homogenize soft tissue. Experimental studies of histotripsy cavitation have shown that the extent of ablation in different tissues depends on tissue mechanical properties and waveform parameters. Variable tissue susceptibility to the large stresses, strains, and strain rates developed by cavitation bubbles has been suggested as a basis for localized liver tumor treatments that spare large vessels and bile ducts. However, field quantities developed within microns of cavitation bubbles are too localized and transient to measure in experiments. Previous numerical studies have attempted to circumvent this challenge but made limited use of realistic tissue property data. In this study, numerical simulations are used to calculate stress, strain, and strain rate fields produced by bubble oscillation under histotripsy forcing in a variety of tissues with literature-sourced viscoelastic and acoustic properties. Strain field calculations are then used to predict a theoretical damage radius using tissue ultimate strain data. Simulation results support the hypothesis that differential tissue responses could be used to design tissue-selective treatments. Results agree with studies correlating tissue ultimate fractional strain with resistance to histotripsy ablation and are also consistent with experiments demonstrating smaller lesion size under exposure to higher frequency waveforms. Methods presented in this study provide an approach for modeling tissue-selective cavitation damage in general. … (more)
- Is Part Of:
- Physics in medicine & biology. Volume 64:Number 22(2019:Nov.)
- Journal:
- Physics in medicine & biology
- Issue:
- Volume 64:Number 22(2019:Nov.)
- Issue Display:
- Volume 64, Issue 22 (2019)
- Year:
- 2019
- Volume:
- 64
- Issue:
- 22
- Issue Sort Value:
- 2019-0064-0022-0000
- Page Start:
- Page End:
- Publication Date:
- 2019-11-15
- Subjects:
- cavitation -- histotripsy -- bubble dynamics -- tissue damage -- cavitation injury -- cavitation in soft matter
Biophysics -- Periodicals
Medical physics -- Periodicals
610.153 - Journal URLs:
- http://ioppublishing.org/ ↗
http://iopscience.iop.org/0031-9155 ↗ - DOI:
- 10.1088/1361-6560/ab5010 ↗
- Languages:
- English
- ISSNs:
- 0031-9155
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 14095.xml