Physiochemical properties and paclitaxel release behaviors of dual-stimuli responsive copolymer-magnetite superparamagnetic nanocomposites. (18th January 2019)

• Record Type: Journal Article
• Authors: Liu, Yu; Li, Yang; Rao, Zikun; Xu, Jinshan; Zhao, Shichao; Zhao, Cong; Zhu, Hongyu; Hao, Jianyuan; Yang, Ting; Yang, Yuan
• Is Part Of: Nanotechnology. Volume 30:Number 10(2019)
• Publication Date: 2019-01-18
• Subjects: magnetic responsiveness -- pH-responsive release -- nanocomposites; Nanotechnology -- Periodicals; Nanotechnology -- Periodicals; Nanotechnology; Publications périodiques; Nanotechnologies; Periodicals; 620.5
• DOI: 10.1088/1361-6528/aaf9ec
• Languages: English
• ISSNs: 0957-4484

Abstract

Abstract: Magnetically driven drug delivery systems of superparamagnetic iron oxide nanoparticles have a considerable potential as candidates to overcome the present obstacles of drug delivery in anti-tumor therapy owing to its remote controllability by external magnetic fields and other unique properties. In this work, a biodegradable anionic copolymer with side carboxylic groups named methoxy-poly (ethylene glycol)-block-poly( α -carboxyl- ε -caprolactone) was synthesized to complex iron oxide magnetic nanoparticles and load paclitaxel (PTX) to form dual-stimuli responsive copolymer-magnetite superparamagnetic nanocomposites with an elastic core and carboxylic groups on the surface in a very easy way. The physiochemical properties of these nanocomposites were measured. High PTX loading content and high saturation magnetization were obtained. Being proved to be stable at a wide pH range and low cytotoxic in vitro, these nanocomposites presented faster PTX release in vitro at pH 6.5 than at pH 7.4 and obviously reduced burst release.