Anti-glomerular basement membrane nephritis with bronchial carcinoma: a case report. Issue 3 (October 2020)

• Record Type: Journal Article
• Authors: Gao, Chenni; Xie, Jingyuan; Pan, Xiaoxia; Chen, Xiaonong
• Is Part Of: Journal of international medical research. Volume 48:Issue 3(2020)
• Publication Date: 2020-10
• Subjects: Acute kidney injury -- anti-glomerular basement membrane (anti-GBM) nephritis -- bronchial carcinoma -- cyclophosphamide -- methylprednisolone -- plasmapheresis; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060519892397
• Languages: English
• ISSNs: 0300-0605

Abstract

Renal insufficiency is common among patients with various types of malignant tumors. However, the occurrence of anti-glomerular basement membrane (GBM) nephritis in a patient with a malignant tumor is relatively rare. Here, we describe a patient with bronchial carcinoma who exhibited acute kidney injury, hematuria, and non-nephrotic-range proteinuria. The patient had positive serum anti-GBM antibody findings and biopsy-proven anti-GBM nephritis. This is a rare instance of anti-GBM nephritis in a patient with a malignant solid tumor. Neoplasia was presumed to contribute to the development of anti-GBM nephritis through secretion of tumor-related antigens or unusual exposure to GBM.