Facile synthesis of cetyltrimethylammonium bromide-loaded mesoporous silica nanoparticles for efficient inhibition of hepatocellular carcinoma cell proliferation. (19th August 2020)

• Record Type: Journal Article
• Authors: Ai, Fulu; Zhao, Guohua; Lv, Wu; Lin, Jie
• Is Part Of: Materials research express. Volume 7:Number 8(2020)
• Publication Date: 2020-08-19
• Subjects: mesoporous silica nanoparticles -- CTAB -- cancer treatment -- Human Hepatoma Cells; Materials science -- Research -- Periodicals; Materials science -- Periodicals; 620.11
• DOI: 10.1088/2053-1591/abad15
• Languages: English
• ISSNs: 2053-1591

Abstract

Abstract: We report the synthesis of cetyltrimethylammonium bromide (CTAB)-loaded mesoporous silica nanoparticles (MSNs) as efficient anticancer agents. The chemical composition and structure, drug loading capacity, and in vitro cytotoxicity of CTAB-MSNs were analyzed. Our results reveal that CTAB-MSNs display a uniform pore structure, extensive surface area, and high drug-loading capacity, of approximately 37.2% by weight. The viability assessments showed that CTAB-MSNs exhibited superior human hepatoma (HepG2) cell killing compared to free CTAB. Therefore, CTAB-MSNs may have advantages over conventional cancer therapies.