A study on a special DNA nanotube assembled from two single-stranded tiles. (25th January 2019)

• Record Type: Journal Article
• Authors: Xu, Fei; Wu, Tingfang; Shi, Xiaolong; Pan, Linqiang
• Is Part Of: Nanotechnology. Volume 30:Number 11(2019)
• Publication Date: 2019-01-25
• Subjects: DNA nanotube -- self-assembly -- hierarchical assembly -- DNA nanotechnology -- drug delivery; Nanotechnology -- Periodicals; Nanotechnology -- Periodicals; Nanotechnology; Publications périodiques; Nanotechnologies; Periodicals; 620.5
• DOI: 10.1088/1361-6528/aaf9bc
• Languages: English
• ISSNs: 0957-4484

Abstract

Abstract: Single-stranded tile (SST) strategy offers precise control over the circumferences of nanotubes while the kinetic trap in the process of the self-assembly prevents the formation of wider tubes. Here, we report a simple and efficient method to build DNA nanotubes using only 2 SSTs via one-pot annealing. The diameters of the 2-SST nanotubes were much larger than what the kinetic trap theory would predict, indicating a new mechanism was at play in the formation of these nanotubes. Further investigation suggested that the 2-SST nanotubes were assembled through a hierarchical pathway that involved an intermediate formation of 2-SST nano-lines.