3 tera-basepairs as a fundamental limit for robust DNA replication. (30th June 2020)

• Record Type: Journal Article
• Authors: Mamun, M Al; Albergante, L; J Blow, J; Newman, T J
• Is Part Of: Physical biology. Volume 17:Number 4(2020:Aug.)
• Publication Date: 2020-06-30
• Subjects: DNA replication -- embryo development -- polyploidy -- robustness -- eutely -- double fork stalls -- theoretical analysis; Biophysics -- Periodicals; Biochemistry -- Periodicals; Biology -- Data processing -- Periodicals; 570.5
• DOI: 10.1088/1478-3975/ab8c2f
• Languages: English
• ISSNs: 1478-3967

Abstract

Abstract: In order to maintain functional robustness and species integrity, organisms must ensure high fidelity of the genome duplication process. This is particularly true during early development, where cell division is often occurring both rapidly and coherently. By studying the extreme limits of suppressing DNA replication failure due to double fork stall errors, we uncover a fundamental constant that describes a trade-off between genome size and architectural complexity of the developing organism. This constant has the approximate value N U ≈ 3 × 10 12 basepairs, and depends only on two highly conserved molecular properties of DNA biology. We show that our theory is successful in interpreting a diverse range of data across the Eukaryota.