Crystallization of aspirin form II by femtosecond laser irradiation. (21st December 2018)

• Record Type: Journal Article
• Authors: Tsuri, Yuka; Maruyama, Mihoko; Fujimoto, Riki; Okada, Shino; Adachi, Hiroaki; Yoshikawa, Hiroshi Y.; Takano, Kazufumi; Murakami, Satoshi; Matsumura, Hiroyoshi; Inoue, Tsuyoshi; Tsukamoto, Katsuo; Imanishi, Masayuki; Yoshimura, Masashi; Mori, Yusuke
• Is Part Of: Applied physics express. Volume 12:Number 1(2019)
• Publication Date: 2018-12-21
• Subjects: Physics -- Periodicals; Technology -- Periodicals; 621.05
• DOI: 10.7567/1882-0786/aaf419
• Languages: English
• ISSNs: 1882-0778

Abstract

Abstract: The selective crystallization of aspirin form II is exceedingly difficult, because the similarity of the crystal structures of form I and form II enable them to intergrow. We succeeded in crystallizing a pure form II crystal by laser irradiation with a precise condition control. The crystal was identified by Raman spectroscopy and in situ observation of the phase transformation from form II into form I. Accordingly, we conclude that this laser-induced crystallization would be applicable to a variety of materials like aspirin for which it is difficult to crystallize polymorphs selectively.