Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension. (March 2020)

• Record Type: Journal Article
• Authors: Richter, Manuel J.; Harutyunova, Satenik; Bollmann, Tom; Classen, Simon; Fuge, Jan; Gall, Henning; Gerhardt, Felix; Ghofrani, Hossein A.; Gunkel, Hartmut; Grünig, Ekkehard; Halank, Michael; Heine, Alexander; Klose, Hans; Lange, Tobias J.; Neurohr, Claus; Nickolaus, Kai; Opitz, Christian F.; Rosenkranz, Stephan; Seyfarth, Hans-Jürgen; Tello, Khodr; Ewert, Ralf; Olsson, Karen M.
• Is Part Of: Pulmonary circulation. Volume 10:Number 1(2020)
• Publication Date: 2020-03
• Subjects: implantable infusion pump -- pulmonary hypertension -- treatment -- prostanoid; Pulmonary circulation -- Periodicals; Pulmonary circulation; Electronic journals -- Sciences; Periodicals; 616.24005
• DOI: 10.1177/2045894020910136
• Languages: English
• ISSNs: 2045-8932

Abstract

Implantable infusion pumps might improve the convenience and safety of intravenous treprostinil for pulmonary arterial hypertension. The LENUS Pro® pump (approved in Europe) has a fixed flow rate. Based on 126 pumps and 2853 refills, we retrospectively analyzed the actual flow rate from 09/2010 to 09/2018. A relevant flow rate variance is evident after three years; therefore, flow rate monitoring and dose adjustment are mandatory.