A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?. (October 2020)

• Record Type: Journal Article
• Authors: Huiskamp, Marijn; Moumdjian, Lousin; van Asch, Paul; Popescu, Veronica; Schoonheim, Menno Michiel; Steenwijk, Martijn D; Vanzeir, Ellen; van Wijmeersch, Bart; Geurts, Jeroen JG; Feys, Peter; Hulst, Hanneke E
• Is Part Of: Multiple sclerosis. Volume 26:Number 12(2020)
• Page Start: 1594
• Page End: 1598
• Publication Date: 2020-10
• Subjects: Multiple sclerosis -- cognitive rehabilitation -- endurance exercise -- functional connectivity -- hippocampus -- default-mode network; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458519863644
• Languages: English
• ISSNs: 1352-4585

Abstract

Background/objective: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS. Methods/results: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention ( n = 15) and waitlist group ( n = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only. Conclusion: As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.