Factors associated with outcomes of septic shock patients receiving high dose noradrenaline according to three primary infection sites. Issue 2 (October 2020)

• Record Type: Journal Article
• Authors: Wu, Kang-song; Gu, Dan-yan; Wang, Ting-ting; Yu, Bu-wen; Pan, Kong-han; Zhou, Jian-cang
• Is Part Of: Journal of international medical research. Volume 48:Issue 2(2020)
• Publication Date: 2020-10
• Subjects: Septic shock -- noradrenaline -- vasopressor -- respiratory -- abdominal -- urinary; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060519874545
• Languages: English
• ISSNs: 0300-0605

Abstract

Objective: To identify factors associated with outcome of septic shock patients receiving high dose noradrenaline according to three primary infection sites. Methods: This retrospective study was based on data from a publicly available ICU database (Medical Information Mart for Intensive Care [MIMIC] III. Septic shock patients receiving high dose (≥1 μg/kg per min) noradrenaline and ≥18 years were identified and their characteristics and outcomes were compared according to three primary infection sites (abdominal, respiratory and urinary tract). Results: 154 septic shock patients who received high doses of noradrenaline were identified; (89 [58%] had a respiratory infection, 41 [27%] an abdominal infection and 24 [16%] a urinary infection). There were no differences among the three infection groups in duration/maximum dosage of noradrenaline, length of stay in the ICU/hospital, do not resuscitate (DNR) rates, hypertension and adequate antimicrobial therapy. Patients with urinary infections had a lower risk of death at 28-days compared with those with abdominal or respiratory infections. Conclusions: The prognosis for septic shock patients receiving high dose noradrenaline is poor. Patients with abdominal or respiratory infections are at higher risk of death compared with those with urinary infections.