Association of ZNF184, IL1R2, LRRK2, ITPKB, and PARK16 with sporadic Parkinson's disease in Eastern China. (14th September 2020) - Gao, Ting
Highlights: Tested 20 novel PD risk loci identified by GWAS in East Asian samples. Allele of LRRK2 and IL1R2 have a higher risk of PD. Genotypic models of ZNF184, PARK16, ITPKB significantly associated with PD. Abstract: Background: Genetic factors may play important roles in the pathogenesis of Parkinson's disease, and more than 40 loci involved in Parkinson's disease have been identified. Due to differing allele frequencies across origins, the associations of these loci and sporadic Parkinson's disease in the Eastern Chinese population are still unclear. Objective: The aim of this study was to investigate the relationship between 20 single nucleotide polymorphisms and Parkinson's disease in the Eastern Chinese population. Methods: A total of 441 Parkinson's disease patients and 384 healthy controls were recruited. The MassARRAY System was used to detect 20 single nucleotide polymorphisms. Odds ratios (OR) were calculated to assess the relationship between polymorphisms and Parkinson's disease susceptibility. Results: We found that ITPKB rs4653767 (OR [95 % confidential interval (CI)] = 0.524 [0.309−0.922], p = 0.023), ZNF184 rs9468199 (OR [95 % CI] = 0.530 [0.326−0.862], p = 0.010), IL1R2 rs34043159 (OR [95 % CI] = 0.794 [0.651−0.968], p = 0.022), LRRK2 rs76904798 (OR [95 % CI] = 0.397 [0.225−0.700], p = 0.001), and PARK16 rs11240572 (OR [95 % CI] = 0.715 [0.531−0.962], p = 0.027) were significantly associated with Parkinson's disease. Conclusions: LRRK2 rs76904798, ZNF184 rs9468199, PARK16 rs11240572, ITPKB rs4653767, and IL1R2 rs34043159 may associate with Parkinson's disease in the Eastern Han Chinese population.