High levels of boron promote anchorage-independent growth of nontumorigenic cells. (November 2020)

• Record Type: Journal Article
• Authors: Xu, Huadong; Hashimoto, Kazunori; Maeda, Masao; Azimi, Mohammad Daud; Fayaz, Said Hafizullah; Chen, Wei; Hamajima, Nobuyuki; Kato, Masashi
• Is Part Of: Environmental pollution. Volume 266:Part 3(2020)
• Publication Date: 2020-11
• Subjects: Boron -- Well drinking water -- Tumorigenic risk -- Tumorigenic pathway; inductively coupled plasma-mass spectrophotometer ICP-MS -- mitogen-activated protein kinase kinase MEK -- extracellular signal-regulated kinase ERK -- phosphoinositide 3-kinase PI3K; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2020.115094
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: WHO has presented a health-based guideline value for boron in drinking water. That fact indicates that a high level of boron is toxic for humans. However, there is no direct evidence of boron-mediated malignant transformation. In this study, human lung epithelial nontumorigenic BEAS-2B cells and tumorigenic A549 cells were used to investigate the tumorigenic toxicity of boron in vitro . Anchorage-independent growth, a hallmark of malignant transformation, was increased by boron at concentrations of 50, 250 and 500 μM in BEAS-2B cells, though the same concentrations of boron had no influence on anchorage-independent growth of A549 cells. Moreover, boron at concentrations of 250 and 500 μM activated the c-SRC/PI3K/AKT pathway of BEAS-2B cells. The results of our in vitro study suggest that exposure to high levels of boron promotes transforming activity of nontumorigenic cells. Graphical abstract: Image 1 Highlights: Discovery of a high level of boron in well drinking water from Kabul, Afghanistan. Promoted anchorage-independent growth of nontumorigenic cells by 50–500 μM boron. Activated c-SRC/PI3K/AKT pathway in nontumorigenic cells by 250 and 500 μM boron. No effect of 50–500 μM boron on anchorage-independent growth of tumorigenic cells. Promoted transforming activity of nontumorigenic cells by high levels of boron in vitro .