Triazole resistance in Aspergillus fumigatus in crop plant soil after tebuconazole applications. (November 2020)

• Record Type: Journal Article
• Authors: Cao, Duantao; Wu, Ruilin; Dong, Suxia; Wang, Feiyan; Ju, Chao; Yu, Sumei; Xu, Shiji; Fang, Hua; Yu, Yunlong
• Is Part Of: Environmental pollution. Volume 266:Part 1(2020)
• Publication Date: 2020-11
• Subjects: Aspergillus fumigatus -- Resistance -- Triazole -- Tebuconazole; Pollution -- Periodicals; Pollution -- Environmental aspects -- Periodicals; Environmental Pollution -- Periodicals; Pollution -- Périodiques; Pollution -- Aspect de l'environnement -- Périodiques; Pollution -- Effets physiologiques -- Périodiques; Pollution; Pollution -- Environmental aspects; Periodicals; Electronic journals; 363.73
• DOI: 10.1016/j.envpol.2020.115124
• Languages: English
• ISSNs: 0269-7491

Abstract

Abstract: Aspergillus fumigatus is the primary agent of invasive aspergillosis (IA) causing high morbidity and mortality in immunocompromised patients. Triazole resistance in A. fumigatus and its sources have gained wide attention. For several years, environmental fungicides use has been proposed as the major cause for triazole resistance in A. fumigatus . However, there are few studies on azole-resistant A. fumigatus (ARAF) selected by triazole fungicides in agricultural systems. We studied the possible emergence of ARAF in the field after exposure to triazole fungicide tebuconazole. Our results showed that exposure to tebuconazole in soil selects for resistance to triazoles in A. fumigatus . The probability of ARAF developing in soils depends upon the concentrations of tebuconazole after application. We suggest that tebuconazole applications should be minimized to reduce selective pressure for the generation of ARAFs. Graphical abstract: Image 1 Highlights: Tebuconazole can induce triazole-resistance in A. fumigatus. Levels of resistance depends upon tebuconazole concentration. More triazole-resistant A. fumigatus were found under greenhouse conditions than under open field conditions. Abstract : Tebuconazole drives emergence of triazole resistant A. fumigatus in agro-ecosystems.