Impact of COVID -19 in cancer patients on severity of disease and fatal outcomes: A systematic review and meta-analysis. Issue 5 (September 2020)

• Record Type: Journal Article
• Authors: Salunke, Abhijeet Ashok; Nandy, Kunal; Pathak, Subodh Kumar; Shah, Jaymin; Kamani, Mayur; Kottakota, Viswanth; Thivari, Praveen; Pandey, Apurva; Patel, Keval; Rathod, Priyank; Bhatt, Supreet; Dave, Pariseema; Pandya, Shashank
• Is Part Of: Diabetes & metabolic syndrome. Volume 14:Issue 5(2020)
• Page Start: 1431
• Page End: 1437
• Publication Date: 2020-09
• Subjects: Corona disease -- COVID-19 -- Cancer -- Non cancer -- ICU Stay -- Mortality rate -- Oncology; Diabetes -- Periodicals; Metabolism -- Disorders -- Periodicals; Diabetes Mellitus -- Periodicals; Metabolic Diseases -- Periodicals; Diabète -- Périodiques; Métabolisme, Troubles du -- Périodiques; Endocrinologie -- Périodiques; Diabète -- Physiopathologie -- Périodiques; Diabetes; Metabolism -- Disorders; Electronic journals; Periodicals; 616.462
• DOI: 10.1016/j.dsx.2020.07.037
• Languages: English
• ISSNs: 1871-4021

Abstract

Abstract: Background and aimsbackground: Currently there is limited knowledge on cancer and COVID-19; we conducted a systematic review and meta-analysis to evaluate the impact of cancer on serious events including ICU admission rate and mortality in COVID 19. Methods: PubMed, Cochrane Central Register of Clinical Trials were searched on April 16, 2020, to extract published articles that reported the outcomes of cancer in COVID-19 patients. The search terms were "coronavirus" and "clinical characteristics" with no language or time restrictions. We identified 512 published results and 13 studies were included in the analysis. Results: There were 3775 patients, of whom 63 (1·66%) had a cancer. The pooled estimates of ICU admission in COVID 19 patients with and without cancer were 40% versus 8·42%.The odds ratio of ICU admission rates between the cancer and non-cancer groups was 2.88 with a 95% CI of 1·18 to 7·01 (p = 0·026). The pooled estimates of death rate in COVID -19 patients with and without cancer were 20·83% versus 7·82%. The odds ratio of death rates between the cancer and non-cancer groups was 2.25 with a 95% CI ranging from 0·71 to 7·10 with p value of 0·166. The pooled prevalence of cancer patients was 2% (95 CI 1–4). Conclusions: Presence of cancer in COVID-19 leads to higher risk of developing serious events i.e. ICU admission, mechanical ventilation and mortality. The presence of cancer has a significant impact on mortality rate in COVID-19 patients. Highlights: COVID-19 in cancer patients is associated with higher morbidity. Patient with Comorbidities are likely to have higher risk of severe events. Cancer has a significant impact on ICU admission rate.