A convenient synthesis of N-tert-butyl amides by the reaction of di-tert-butyl dicarbonate and nitriles catalyzed by Cu(OTf)2. Issue 9 (September 2020)

• Record Type: Journal Article
• Authors: Yang, Wanfeng; Feng, Chengliang; Tang, Yuqi; Ji, Min; Chen, Junqing
• Is Part Of: Journal of chemical research. Volume 44:Issue 9/10(2020)
• Page Start: 602
• Page End: 608
• Publication Date: 2020-09
• Subjects: Cu(OTf)2 -- di-tert-butyl dicarbonate -- nitriles -- Ritter reaction -- room temperature; Chemistry -- Research -- Periodicals; Chemistry -- Periodicals; 540.5
• DOI: 10.1177/1747519820914474
• Languages: English
• ISSNs: 1747-5198

Abstract

The utility of Cu(OTf)2 as the catalyst for the synthesis of a series of N - tert -butyl amides in excellent isolated yields via the reaction of nitriles (alkyl, aryl, benzyl, and furyl nitriles) with di- tert -butyl dicarbonate is described. Cu(OTf)2 is a highly stable and efficient catalyst for the present Ritter reaction under solvent-free conditions at room temperature.