Graphene oxide/alginate/silk fibroin composite as a novel bionanostructure with improved blood compatibility, less toxicity and enhanced mechanical properties. (15th November 2020)

• Record Type: Journal Article
• Authors: Eivazzadeh-Keihan, Reza; Radinekiyan, Fateme; Madanchi, Hamid; Aliabadi, Hooman Aghamirza Moghim; Maleki, Ali
• Is Part Of: Carbohydrate polymers. Volume 248(2020)
• Publication Date: 2020-11-15
• Subjects: Hemolytic assay -- Graphene oxide -- Sodium alginate -- Silk fibroin -- In-vitro hemocompatibility; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.116802
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: Graphene oxide (GO) was modified by polysaccharide sodium alginate (Alg) containing silk fibroin (SF) nanostructure. Enhanced mechanical properties was resulted by GO/Alg/SF nanobiocomposite. Noticeable blood compatibility was exposed by GO/Alg/SF nanobiocomposite. GO/Alg/SF nanobiocomposite showed lowest toxicity comparing with most other scaffolds. The synthesized GO/Alg/SF nanostructure could be used as new wound healing scaffold. Abstract: For biomedical applications, the design and synthesis of biocompatible nanostructures, are considered as critical challenges. In this study, graphene oxide (GO) was covalently modified by natural sodium alginate (Alg) polymer. By adding silk fibroin (SF) to this nanostructure, a hybrid nanobiocomposite (GO/Alg/SF) was resulted and its unique features were determined using FT-IR, EDX, FE-SEM, XRD and TG analyses. Because of using less toxic and high biocompatible materials, specific biological results were achieved. The cell viability of this novel nanostructure was 89.2 % and its hemolytic effect was less than 6% while the highest concentration (1000 μg/mL) of this nanostructure was chosen for these purposes. Also, high mechanical properties including the compressive strength (0.87 ± 0.034 (MPa)) and the compressive modulus (2.25 ± 0.091 (MPa)) were exposed. This nanostructure can be considered as a scaffold for wound dressing applications due to the mentioned properties.