NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens. (November 2020)

• Record Type: Journal Article
• Authors: Xu, Yuling; Zhang, Yi; Li, Jun; An, Jusung; Li, Chonglu; Bai, Suya; Sharma, Amit; Deng, Ganzhen; Kim, Jong Seung; Sun, Yao
• Is Part Of: Biomaterials. Volume 259(2020)
• Publication Date: 2020-11
• Subjects: Aggregation-induced emission -- The second infrared channel -- Organic dye -- Photothermal therapy -- Photodynamic therapy; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2020.120315
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Despite the wide application of the traditional NIR-I phototheranostic platforms in basic research and clinical studies, problems such as tissue scattering, auto-fluorescence combined with aggregation caused quenching hamper precise image-guided phototherapy. Herein, we developed a multifunctional NIR-II phototheranostic platform using a novel AIE-based dye (ZSY-TPE ) for single laser-activated imaging-guided combined photothermal and photodynamic therapies of tumors and pathogens. As confirmed through in vivo studies, the ZSY-TPE dots displayed precise and efficient high-performance NIR-II imaging-guided combination phototherapy against 4T1 tumor as well as S. aureus-infected mice models without any noticeable side effects. The current study demonstrates ZSY-TPE as a powerful phototheranostic platform for precise NIR-II fluorescence/PA imaging and synergistic photodynamic/photothermal therapy of tumors and bacterial infections. Graphical abstract: Image 1