Engineering oral delivery of hydrophobic bioactives in real-world scenarios. (August 2020)

• Record Type: Journal Article
• Authors: Sarkar, Anwesha; Mackie, Alan R.
• Is Part Of: Current opinion in colloid & interface science. Volume 48(2020)
• Page Start: 40
• Page End: 52
• Publication Date: 2020-08
• Subjects: Pickering emulsion -- Nanoemulsion -- Mathematical model -- Bioaccessibility -- Bioavailability -- Release; Surface chemistry -- Periodicals; Colloids -- Periodicals; 541.33
• DOI: 10.1016/j.cocis.2020.03.009
• Languages: English
• ISSNs: 1359-0294

Abstract

Abstract: Bioactive compounds, often hydrophobic in nature, tend to degrade during processing outside or inside the body with rapid clearance rates, resulting in poor bioavailability. In this review, we survey recent scientific advances in lipid-based colloidal delivery systems (conventional emulsions/nanoemulsions, Pickering emulsions, multilayered and multiple emulsions, coated/uncoated liposomes, natural microcapsules, and so on) that have been used to improve the bioaccessibility and/or bioavailability of hydrophobic bioactive compounds. Specifically, we use a 'delivery to design' approach, that is, we discuss the desired release kinetics of bioactive compounds first. This enables us to paint a more reasonable image of the optimal microstructure sought in the gastrointestinal tract, to lay out the design principles for fabricating the next generation of oral delivery carriers. Finally, we outline the challenges for translation of oral delivery vehicles that show promises in benchtop experiments and how multidisciplinary approaches might help overcoming some of those challenges. Graphical abstract: Image 1 Highlights: Colloidal systems continue to be created to deliver hydrophobic bioactive compounds. Mathematical models are crucial to derive kinetic parameters of bioactives. Great emphasis has been laid on in vitro release of bioactives and bioaccessibility. Bioavailability studies of hydrophobic bioactive compounds are scarce in the literature. A 'delivery to design' approach can be used for future tailoring of delivery systems.