Cribriform growth pattern in lung adenocarcinoma: More aggressive and poorer prognosis than acinar growth pattern. (September 2020)

• Record Type: Journal Article
• Authors: Yang, Fujun; Dong, Zhengwei; Shen, Yingran; Shi, Jinghan; Wu, Yulin; Zhao, Zhipeng; Jiang, Gening; Song, Xiao
• Is Part Of: Lung cancer. Volume 147(2020)
• Page Start: 187
• Page End: 192
• Publication Date: 2020-09
• Subjects: Cribriform lung adenocarcinoma -- Clinicopathological features -- Prognosis -- Genetic variations; AAH atypical adenomatous hyperplasia -- AIS adenocarcinoma in situ -- MIA minimal invasive adenocarcinoma -- IA invasive adenocarcinoma -- LPA lepidic predominant adenocarcinoma -- APA acinar predominant adenocarcinoma -- PPA papillary predominant adenocarcinoma -- SPA solid predominant adenocarcinoma -- MPA micropapillary predominant adenocarcinoma -- CPA cribriform predominant adenocarcinoma -- HPF High-Power Field -- STAS tumor spread through air spaces -- OR odds ratio -- RFP recurrence-free probability -- HR hazard ratio -- RFS recurrence-free survival -- OS overall survival -- DFS disease-free survival -- PRS post-recurrence survival -- KRAS kirsten rat sarcoma viral oncogene -- ALK anaplastic lymphoma kinase -- ROS1 ROS proto-oncogene 1, receptor tyrosine kinase -- RET ret proto-oncogene -- EGFR epidermal growth factor receptor -- CIR cumulative incidence recurrence; Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2020.07.021
• Languages: English
• ISSNs: 0169-5002

Abstract

Highlights: Cribriform growth pattern is more aggressive than acinar growth pattern in lung adenocarcinoma. Cribriform component present were associated with increased risk of recurrence and death compared with acinar pattern. Cribriform component was associated with fusion gene mutations (ALK, ROS1, and RET). Abstract: The predictive value of prognosis based on the histopathological subtype is a critical criterion in the new classification of lung adenocarcinoma published in 2011 by the International Association for the Study of Lung Cancer (IASLC), the American Thoracic Society (ATS), and the European Respiratory Society (ERS) (IASLC/ATS/ERS). In this new classification, the differences of histopathology and prognosis are two considerable parameters to classify the subtypes of lung adenocarcinoma. Cribriform growth pattern is regarded as a variant of acinar growth pattern in lung adenocarcinoma, however, more and more studies pointed out that cribriform growth pattern is associated with more aggressive histopathological structures, higher proportion of recurrence rates, and shorter postoperative survival than acinar growth pattern. These features are similar to solid or micropapillary predominant adenocarcinoma. In this review, we summarized the clinicopathological features, prognosis, and genetic variations of cribriform growth pattern of lung adenocarcinoma, and provided a novel insight into the diagnosis and treatment of cribriform lung adenocarcinoma.